Vigora 100 mg contains the active ingredient sildenafil citrate, which is a phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED) in men. Several medications can interact with sildenafil citrate, potentially affecting its effectiveness, increasing the risk of side effects, or causing adverse reactions. Here are some classes of medications that may interact with Vigora 100 mg:

Nitrates: The concomitant use of sildenafil citrate with nitrates or nitric oxide donors (e.g., nitroglycerin, isosorbide mononitrate, isosorbide dinitrate) is contraindicated. Combining sildenafil with nitrates can lead to a significant drop in blood pressure, resulting in hypotension (low blood pressure), dizziness, fainting, and even cardiovascular complications. Nitrates are commonly used to treat chest pain (angina) and heart-related conditions.

Alpha-Blockers: Alpha-blockers (e.g., doxazosin, tamsulosin, alfuzosin) are medications used to treat high blood pressure (hypertension) and benign prostatic hyperplasia (BPH). When taken with sildenafil citrate, alpha-blockers can potentiate the hypotensive effects, leading to a further decrease in blood pressure. Caution and dose adjustments may be necessary if these medications are used together.

Antihypertensive Medications: Other medications used to lower blood pressure, such as beta-blockers, calcium channel blockers, angiotensin-converting enzyme (ACE) inhibitors, and angiotensin II receptor blockers (ARBs), may also interact with sildenafil citrate and increase the risk of hypotension. Healthcare providers may need to adjust the dosages of these medications if used concurrently with Vigora 100 mg.

Other PDE5 Inhibitors: Concurrent use of sildenafil citrate with other PDE5 inhibitors (e.g., tadalafil, vardenafil, avanafil) is not recommended due to the additive effects on blood pressure and the increased risk of adverse effects.

HIV Protease Inhibitors: Certain antiretroviral medications used to treat HIV/AIDS, known as protease inhibitors (e.g., ritonavir, saquinavir), can increase the plasma levels of sildenafil citrate, potentially leading to an increased risk of adverse effects. Dose adjustments may be necessary if sildenafil is used concomitantly with these medications.

CYP3A4 Inhibitors: Sildenafil citrate is metabolized primarily by the cytochrome P450 enzyme CYP3A4. Medications that inhibit CYP3A4 activity (e.g., ketoconazole, itraconazole, erythromycin, clarithromycin, ritonavir) can increase the plasma levels of sildenafil, potentially intensifying its effects and increasing the risk of adverse reactions.

It’s essential to inform your healthcare provider about all medications, supplements, and herbal products you are taking before starting treatment with Vigora 100 mg. They can assess the potential for drug interactions and adjust your treatment plan accordingly to ensure your safety and optimize the effectiveness of therapy.