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Most Mutalyzer functionality is programmatically available through two interfaces: a SOAP web service and a HTTP/RPC+JSON web service. A WSDL description is available for easy generation of client programs in many languages. [...] The following are some example client programs for SOAP web service. [...] Example: checkSyntax?variant=AB026906.1:c.274del For now, you can work from this example using the above mentioned annotated SOAP API, since the HTTP/RPC+JSON web service mirrors the functionality of the SOAP web service.